Family Curator Notes

# molecular_function
20140604: Has function calcium channel inhibitor activity (GO:0019855) in Opisthokonta_PTN000828346
20110126: Has function peptidyl-prolyl cis-trans isomerase activity (GO:0003755) in root_PTN000054102
20110126: Has function FK506 binding (GO:0005528) in root_PTN000054102
# cellular_component
20140604: Has function sarcoplasmic reticulum membrane (GO:0033017) in Amniota_PTN001314565
20140604: Has function endoplasmic reticulum membrane (GO:0005789) in root_PTN000054497
20140604: Has function chloroplast (GO:0009507) in root_PTN000828817
20140604: Has function cytoplasm (GO:0005737) in root_PTN000054102
# biological_process
20140604: Has function regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO:0010881) in Amniota_PTN001314565
20140604: Has function negative regulation of release of sequestered calcium ion into cytosol (GO:0051280) in Opisthokonta_PTN000828346
20140604: Has function chaperone-mediated protein folding (GO:0061077) in root_PTN000054102
20140604: Has function protein peptidyl-prolyl isomerization (GO:0000413) in root_PTN000054102
# Notes
# Notes

MSL Fast-pass curation 2011-02-11
PG Reviewed family 2014-06-04

Annotation inferences using phylogenetic trees

The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).