Tree Node Information

Stable PANTREE ID: PTN000215053
Parent Id: PTN000215052
Family: FORKHEAD BOX PROTEIN
More curation information: Curator notes   All family Annotations
View Tree: Tree
Event Type: SPECIATION
Node Type: INTERNAL
Reference speciation event: Catarrhini
Branch Length: 0.000

DIRECT ANNOTATIONS TO THIS NODE

No direct annotations to node

ANNOTATIONS INHERITED BY THIS NODE

ANNOTATION DESCENDANTS PROVIDING EXPERIMENTAL EVIDENCE DIRECTLY ANNOTATED ANCESTOR
DNA binding, bending UniProtKB:Q12952, UniProtKB:Q12948 PTN000215025
pattern specification process FB:FBgn0004567, WB:WBGene00004013, ZFIN:ZDB-GENE-000616-15, MGI:MGI:1347465, MGI:MGI:1347481, MGI:MGI:1347466, MGI:MGI:1927549, ZFIN:ZDB-GENE-980526-423, MGI:MGI:1347476, MGI:MGI:1347474, ZFIN:ZDB-GENE-980605-4, UniProtKB:O75593, FB:FBgn0014143, ZFIN:ZDB-GENE-060929-1178, ZFIN:ZDB-GENE-041212-76, ZFIN:ZDB-GENE-010302-1, MGI:MGI:1347463, FB:FBgn0003430, MGI:MGI:1347472, MGI:MGI:1347470, FB:FBgn0000659 PTN000215025
embryo development FB:FBgn0004567, WB:WBGene00004013, ZFIN:ZDB-GENE-030505-1, MGI:MGI:1927549, UniProtKB:Q12946, ZFIN:ZDB-GENE-980605-4, FB:FBgn0045759, ZFIN:ZDB-GENE-990708-6, FB:FBgn0014143, FB:FBgn0015396, ZFIN:ZDB-GENE-010302-1, MGI:MGI:2148705, MGI:MGI:1914004, MGI:MGI:1096329, FB:FBgn0003430, MGI:MGI:1353500, WB:WBGene00006853, ZFIN:ZDB-GENE-061116-1, MGI:MGI:1347465, FB:FBgn0004895, ZFIN:ZDB-GENE-000616-15, MGI:MGI:1347481, MGI:MGI:1347466, WB:WBGene00001434, ZFIN:ZDB-GENE-980526-423, MGI:MGI:1347476, ZFIN:ZDB-GENE-980526-404, MGI:MGI:1349428, FB:FBgn0029504, ZFIN:ZDB-GENE-060929-1178, ZFIN:ZDB-GENE-041212-76, MGI:MGI:1347473, FB:FBgn0004898, MGI:MGI:1347472, FB:FBgn0004897, MGI:MGI:1347470, FB:FBgn0000659, FB:FBgn0004896 PTN000215025
tissue development RGD:3970, UniProtKB:P55317, ZFIN:ZDB-GENE-030505-1, MGI:MGI:1927549, RGD:2809, UniProtKB:Q9Y261, UniProtKB:Q12946, WB:WBGene00001438, FB:FBgn0045759, UniProtKB:O75593, UniProtKB:Q99958, FB:FBgn0015396, ZFIN:ZDB-GENE-010302-1, ZFIN:ZDB-GENE-980526-143, MGI:MGI:2148705, MGI:MGI:1347463, MGI:MGI:1914004, FB:FBgn0003430, ZFIN:ZDB-GENE-990415-78, MGI:MGI:1353500, UniProtKB:O15353, UniProtKB:Q92949, ZFIN:ZDB-GENE-061116-1, MGI:MGI:1347465, ZFIN:ZDB-GENE-040426-1181, ZFIN:ZDB-GENE-000616-15, MGI:MGI:1347481, MGI:MGI:1347466, ZFIN:ZDB-GENE-980526-423, UniProtKB:P58012, MGI:MGI:1347476, ZFIN:ZDB-GENE-980526-404, MGI:MGI:1347474, MGI:MGI:1298228, MGI:MGI:1349428, MGI:MGI:102949, ZFIN:ZDB-GENE-060929-1178, ZFIN:ZDB-GENE-041212-76, ZFIN:ZDB-GENE-031126-4, ZFIN:ZDB-GENE-031126-3, MGI:MGI:1347472, MGI:MGI:1347470, FB:FBgn0000659 PTN000215025
protein homodimerization activity MGI:MGI:1891436, UniProtKB:Q9BZS1, MGI:MGI:2148705, UniProtKB:O15409, MGI:MGI:1914004 PTN000215041
protein heterodimerization activity MGI:MGI:2148705, MGI:MGI:1914004 PTN000215041
chromatin binding MGI:MGI:1914004 PTN000215041
cytoplasm MGI:MGI:1891436, UniProtKB:Q9BZS1 PTN000215041
lung development MGI:MGI:1914004 PTN000215103
cardiac muscle cell differentiation MGI:MGI:1914004 PTN000215103
positive regulation of epithelial cell proliferation MGI:MGI:1914004 PTN000215103
immunoglobulin V(D)J recombination MGI:MGI:1914004 PTN000215103
pre-B cell differentiation MGI:MGI:1914004 PTN000215103
positive regulation of immunoglobulin production MGI:MGI:1914004 PTN000215103
B cell homeostasis MGI:MGI:1891436 PTN000215049
NFAT protein binding UniProtKB:Q9BZS1 PTN000215049
regulation of isotype switching to IgG isotypes MGI:MGI:1891436 PTN000215049
positive regulation of histone acetylation MGI:MGI:1891436, UniProtKB:Q9BZS1 PTN000215049
negative regulation of histone deacetylation UniProtKB:Q9BZS1 PTN000215049
negative regulation of interleukin-6 production MGI:MGI:1891436 PTN000215049
negative regulation of isotype switching to IgE isotypes MGI:MGI:1891436 PTN000215049
positive regulation of immature T cell proliferation in thymus MGI:MGI:1891436 PTN000215049
positive regulation of transforming growth factor beta1 production MGI:MGI:1891436 PTN000215049
negative regulation of interleukin-2 biosynthetic process MGI:MGI:1891436, UniProtKB:Q9BZS1 PTN000215049
positive regulation of T cell anergy MGI:MGI:1891436 PTN000215049
transcription corepressor activity MGI:MGI:1891436 PTN000215049
positive regulation of peripheral T cell tolerance induction MGI:MGI:1891436 PTN000215049
myeloid cell homeostasis MGI:MGI:1891436 PTN000215049
negative regulation of T cell proliferation MGI:MGI:1891436, UniProtKB:Q9BZS1 PTN000215049
T cell receptor signaling pathway MGI:MGI:1891436 PTN000215049
negative regulation of NF-kappaB transcription factor activity UniProtKB:Q9BZS1 PTN000215049
negative regulation of interleukin-5 production MGI:MGI:1891436 PTN000215049
positive regulation of transcription from RNA polymerase II promoter MGI:MGI:1891436, UniProtKB:Q9BZS1 PTN000215049
negative regulation of interleukin-4 production MGI:MGI:1891436, UniProtKB:Q9BZS1 PTN000215049
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation MGI:MGI:1891436 PTN000215049
negative regulation of CREB transcription factor activity UniProtKB:Q9BZS1 PTN000215049
negative regulation of interleukin-2 production MGI:MGI:1891436, UniProtKB:Q9BZS1 PTN000215049
negative regulation of T cell cytokine production UniProtKB:Q9BZS1 PTN000215049
negative regulation of tumor necrosis factor production MGI:MGI:1891436 PTN000215049
negative regulation of cytokine secretion UniProtKB:Q9BZS1 PTN000215049
negative regulation of chronic inflammatory response MGI:MGI:1891436 PTN000215049
tolerance induction to self antigen MGI:MGI:1891436 PTN000215049
negative regulation of interleukin-10 production MGI:MGI:1891436, UniProtKB:Q9BZS1 PTN000215049
histone deacetylase binding UniProtKB:Q9BZS1 PTN000215049
negative regulation of interferon-gamma production MGI:MGI:1891436, UniProtKB:Q9BZS1 PTN000215049
negative regulation of histone acetylation MGI:MGI:1891436 PTN000215049
histone acetyltransferase binding UniProtKB:Q9BZS1 PTN000215049
negative regulation of interferon-gamma biosynthetic process MGI:MGI:1891436 PTN000215049

Sequence